Evansville is a city and the county seat of Vanderburgh County, Indiana, United States. The population was 117,429 at the 2010 census, making it the state's third-most populous city after Indianapolis and Fort Wayne, the largest city in Southern Indiana, and the 232nd-most populous city in the United States. It is the commercial, medical, and cultural hub of Southwestern Indiana and the Illinois-Indiana-Kentucky tri-state area, home to over 911,000 people. The 38th parallel crosses the north side of the city and is marked on Interstate 69.Situated on an oxbow in the Ohio River, the city is often referred to as the "Crescent Valley" or "River City". As a testament to Ohio's grandeur, early French explorers named it La Belle Riviere. The area has been inhabited by various cultures for millennia, dating back at least 10,000 years. Angel Mounds was a permanent settlement of the Mississippian culture from 1000 AD to around 1400 AD. The city was founded in 1812.